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KMID : 1149220170250030337
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Korean Journal of Oriental Medical Prescription
2017 Volume.25 No. 3 p.337 ~ p.347
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Effects of Samhwangsasim-tang Gamibang on Atopic Dermatitis in Mice
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Lee Ho-Chan
Jung Min-Young
Choi Jeong-Hwa
Park Soo-Yeon
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Abstract
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Objectives : Atopic Dermatitis (AD) is chronic skin disease characterized by allergic hypersensitivity reactions. Samhwangsasim-tang Gamibang(SHSST) can treat skin disease by cooling down blood heat, clearing away congenital fever and detoxicating. This study was conducted to investigate the effects of SHSST on AD induced by oxazolone in mice.
Methods : We investigated the effects of SHSST on skin tickness, skin lesions, erythema and melanin index, water content and histopathological changes in vivo. The effects on body weights and spleen body weight ratio were also investigated in mice with AD.
Results : In our results, oral administration of SHSST ameliorated skin lesion such as flare, erythema, exudate and petechia and lowered skin thickness induced by oxazolone. In addition, SHSST lowered erythema index and elevated water content compared to AD control respectively. In the histopathological observation, oral administration of SHSST prevented epidermal hyperplasia and spongiotic changes which is a hallmark of skin inflammation respectively. Finally, SHSST did not affect spleen/body weight ratio.
Conclusions : These data imply that SHSST can ameliorate skin lesion of AD such as flare, erythema, exudate and petechia, and be used to treat AD patients with relative safety
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KEYWORD
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Samhwangsasim-tang Gamibang(SHSST) , Atopic Dermatitis (AD) , oxazolone , skin inflammation
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